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Abstract #0059

Optimal Acquisition Protocol for White Matter Fiber Orientation Mapping Using Generalized CSA-ODF Reconstruction

Amith J. Kamath1, Iman Aganj2, 3, Junqian Xu4, Essa S. Yacoub4, Kamil Ugurbil4, Guillermo Sapiro5, Christophe Lenglet4

1Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States; 2Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, United States; 3Electrical and Computer Engineering, MIT, Cambridge, MA, United States; 4Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 5Electrical and Computer Engineering, Duke University, Durham, NC, United States

This work elaborates guidelines for sampling schemes to be used with a multi-shell diffusion MRI acquisition. The reconstruction is based on the CSA-ODF model and we use the Camino toolkit to generate synthetic data for simulations. By varying the b-value, Spherical Harmonics order, SNR and number of gradient directions, we conclude with the observation that b-values including 1000, 2000, and a third shell in the range [3000, 6000] s/mm2 shows better reconstructions, and that 200 total gradient directions appear sufficient.