Alex J. Barker1, Krishna C. Bandi2, Julio Garcia1, Pim van Ooij1, Patrick McCarthy2, James C. Carr1, S Chris Malaisrie2, Michael Markl1
1Radiology, Northwestern University, Chicago, IL, United States; 2Cardiac Surgery, Northwestern University, Chicago, IL, United States
In this study, the measurement of viscous energy loss, a parameter which is directly responsible for increased cardiac afterload and is independent of pressure recovery effects, was used to quantify LV loading in the presence of aortic valve disease (AVD). A theoretical basis for the technique is presented and applied in-vivo using 4D flow MRI in a range of healthy, dilated aorta, and aortic stenosis (AS) subjects (n=26). Abnormal flow features, combined with systolic flow jets and flow-jet/wall impingement, resulted in statistically elevated energy loss for dilated (0.080.02W, p=0.011) and AS patients (0.810.42W, p<0.001), compared to healthy volunteers (0.050.02W).