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Abstract #0089

Gd-Staining Reveals the Efficacy of an Anti-A&[beta] Antibody to Decrease Amyloid Plaque Load in Vivo in a Transgenic Mouse Model of Alzheimer's Disease

Mathieu David Santin1, 2, Thomas Debeir3, Thierry Delzescaux2, 4, Anne-Sophie Herard2, 4, Caroline Cohen3, Laurent Pradier3, Thomas Rooney3, Marc Dhenain2, 4

1Centre de Neuroimagerie de Recherche CENIR, Institut du Cerveau et de la Moelle pinire ICM, Paris, France; 2URA 2210 CEA/CNRS, Fontenay-aux-Roses, France; 3Therapeutic Strategy Unit Aging, Sanofi, Chilly-Mazarin, France; 4MIRCen, CEA / I2BM, Fontenay-aux-Roses, France

This work describes the use of Gd-Staining MRI to quantify the efficacy of an immunotherapy in a mouse model of cerebral amyloidosis. We showed that this technique is suitable for longitudinal studies and provided age-associated increase of amyloid plaques in transgenic mice.