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Abstract #0117

In Vivo Cardiac 1H MRS, 31P MRS, and MRI in Mouse Models of Increased Fatty Acid Oxidation with and Without Myocardial Lipid Accumulation

Desiree Abdurrachim1, Jolita Ciapaite1, Michel van Weeghel2, Bart Wessels1, Klaas Nicolay1, Sander M. Houten2, Jeanine J. Prompers1

1Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands; 2Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, Netherlands

Using a combination of in vivo 1H MRS, 31P MRS, and MRI, we investigated the relative roles of cardiac lipotoxicity and impaired cardiac energetics in the development of cardiac dysfunction, using mouse models of increased fatty acid oxidation with and without myocardial lipid accumulation. In the mouse model with myocardial lipid accumulation, cardiac energy status was normal, whereas in the mouse model without myocardial lipid accumulation, cardiac energy status was reduced. Interestingly, in both mouse models, a similar degree of cardiac dysfunction was observed, suggesting that myocardial lipid accumulation and disturbances in cardiac energetics independently contribute to reduced cardiac performance.