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Abstract #0146

Correlation Between Quantitative Delayed Contrast-Enhancement in Meniscus and Cartilage in Knee Osteoarthritis

Jasper van Tiel1, 2, Esther Bron1, 3, Koen Bos2, Stefan Klein1, 3, Max Reijman2, Jan Verhaar2, Gabriel Krestin1, Harrie Weinans2, 4, Gyula Kotek1, Edwin Oei1

1Radiology, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands; 2Orthopedic Surgery, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands; 3Medical Informatics, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands; 4Biomechanical Engineering, Delft University of Technology, Delft, Zuid-Holland, Netherlands

We investigated the relation between delayed contrast-enhancement of an ionic contrast agent in the meniscus and adjacent cartilage in early stage knee osteoarthritis patients. We observed a moderate to strong relation between contrast uptake into both structures after a 1.5 hour delay. This finding is in agreement with the outcomes of previous research in which semi-quantitative whole joint assessment on MR images showed a relation between meniscal damage and cartilage loss. However, our results also raise a question about the specificity of delayed gadolinium-enhanced MRI of cartilage for sGAG content in (osteoarthritic) cartilage.