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Abstract #0151

in-vivo 29Si Magnetic Resonance Imaging of Hyperpolarized Silicon Particles

Maja Cassidy1, Henry Chan2, Pratip Bhattacharya2, 3, Charles Marcus1, 4

1Harvard University, Cambridge, MA, United States; 2Huntington Medical Research Institutes, Pasadena, CA, United States; 3Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, United States; 4University of Copenhagen, Copenhagen, Denmark

We report direct in-vivo imaging of hyperpolarized silicon microparticles by 29Si MRI. Hyperpolarization of the 29Si nuclei is generated by dynamic nuclear polarization using electronic defects that naturally occur at the particle surface, and so no additional radical is required. Applications to gastrointestinal, intravascular, and tumor perfusion imaging at sub-picomolar concentrations are presented.