Ultra-High-Field 7T in Vivo Normative Atlas of the Hippocampal Subfields Using Susceptibility Weighted Imaging

Maged Goubran¹, Brendan Santyr¹, Dave A. Rudko¹, Joseph S. Gati¹, Trevor Szekeres¹, Terry M. Peters¹, Ali R. Khan¹

The hippocampus and its substructures are of great importance in the pre-operative evaluation of intractable epilepsy. Quantitative MRI sequences have the added benefit of providing additional information, such as T2* relaxation time and quantitative volume magnetic susceptibility of hippocampal substructures. This work focuses on the construction of a normative atlas of the hippocampal subfields from in vivo susceptibility weighted images of eighteen healthy volunteers on 7T MRI. Using a reliable manual delineation protocol of the subfields, we demonstrated the feasibility of using our atlas in voxel based and morphometry analysis of the hippocampus.