Susceptibility Mapping Using Regularization Enabled Harmonic Artifact Removal

Hongfu Sun¹, Alan H. Wilman¹

A new phase/field artifact removal method is introduced that is based on the SHARP (Sophisticated Harmonic Artifact Reduction for Phase data) method exploiting the harmonic mean value property. This new method employs Tikhonov regularization at the deconvolution stage of the mean value implementation, and is referred to as Regularization Enabled SHARP (RESHARP). RESHARP was compared to SHARP in a field-forward susceptibility simulation and in human brain experiments, demonstrating that it removes background field artifact more effectively compared to SHARP, leading to susceptibility maps with fewer artifacts and more accurate susceptibility measurement in deep grey matter structures.