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Abstract #0175

Quantitative Assessment of Cerebral Metabolism Rate of Oxygen in Neonates

Peiying Liu1, Hao Huang1, Nancy K. Rollins2, Tina Jeon1, Lina Chalak3, Hanzhang Lu1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States; 3Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States


Cerebral metabolic rate of oxygen (CMRO2) is thought to be a direct index of neural activity. However, in vivo measurement of CMRO2 has proven challenging particularly for neonatal population. In this study, we proposed a CMRO2 method for neonates that can be used in any facility with a standard MRI scanner. Preliminary testings have shown great promises of this approach. Although it is a global measure and lacks regional information, several features of this technique (no exogenous agent, <5 min in scan duration, available on a standard 3T) make it a potentially important tool in functional assessment of neonatal population.