The Structural Connectome of the Human Brain in Agenesis of the Corpus Callosum

Julia P. Owen¹, Yi-Ou Li¹, Etay Ziv¹, Zoe Strominger², Jacquelyn Gold², Polina Bukshpun², Mari Wakahiro², Elliott Sherr², Pratik Mukherjee¹

In this work, we investigate he alterations to the global network architecture in the brains of subjects with agenesis of the corpus callosum (AgCC). AgCC is a common congenital brain malformation that results in the complete absence of the corpus callosum. The full extent of the changes in white matter connectivity in AgCC has not been explored. Here, we use MR structural connectomics to reveal the difference in the brain network topology between AgCC and healthy control subjects. This systems level approach motivates the future application of connectomics to the malformed brain.