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Abstract #0197

Simultaneous Diffusion MRI and PET Imaging of Breast Cancer Patients

Eric E. Sigmund1, Sungheon Kim1, Christian Geppert2, Linda Moy3, David Faul2, Christopher B. Glielmi4, Kimberly Jackson3, Kamil Bani-baker3, Amy Melsaether3

1Radiology, NYU Langone Medical Center, Bernard and Irene Schwartz Center for Biomedical Imaging, New York, NY, United States; 2Siemens Medical Systems, New York, NY, United States; 3Radiology, NYU Langone Medical Center, New York, NY, United States; 4Siemens Medical Systems, New York, NY, United States

Diffusion-weighted MRI and fluorodeoxyglucose positron emission tomography (FDG-PET) have diagnostic and prognostic utility in breast cancer imaging, but their inter-correlation and different specificities remain to be established. We employed simultaneous MR/PET, after PET/CT without additional FDG injection, in a cohort of 3 breast cancer patients with a dedicated breast coil. Results were collected for diffusion-weighted imaging, post-Gd contrast imaging, and PET. Intravoxel incoherent motion (IVIM) analysis allowed quantification of tissue diffusivity and perfusion fraction in cancerous lesions, fibroglandular tissue, and other entities. Preliminary results confirm typical trends of malignancy but also suggest the enhanced specificity of the multiparametric MR/PET exam.