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Abstract #0202

Comparison of a High Spatial Resolution DTI Sequence to Standard DTI for Evaluating Fractional Anisotropy of Breast Tumors

Lisa J. Wilmes1, Cheng-Liang Liu1, David C. Newitt1, Suchandrima Banerjee2, Rebekah L. McLaughlin1, Evelyn Proctor1, Emine U. Saritas3, Ajit Shankaranarayanan2, Nola M. Hylton1

1University of California San Francisco, San Francisco, CA, United States; 2GE Healthcare, Menlo Park, CA, United States; 3University of California Berkeley, Berkeley, CA, United States

A high-resolution diffusion tensor imaging sequence (HR-DTI), was compared to a standard FOV DTI sequence (std-DTI), for evaluating tumor and normal-appearing fibroglandular tissue in ten patients with invasive breast cancer. The apparent diffusion coefficients (ADCs) of tumor and normal breast tissue were significantly different for both HR-DTI (p<0.05) and STD-DTI (p<0.05). A significant difference in the fractional anisotropy (FA) between tumor and normal-appearing fibroglandular tissue was found for HR-DTI (p<0.05) but not for STD-DTI. These preliminary results suggest that high resolution FA may provide improved discrimination between tumor and normal breast tissue compared to standard resolution FA.