The Robustness of DSC-PWI for Acute Stroke Imaging; Timing Is Everything: The Vanishing Perfusion Abnormality.

Irene Klaerke Mikkelsen¹, Lars Riisgaard Ribe¹, Susanne Lise Bekke¹, Kim Mouridsen¹, Leif stergaard¹

In patients with acute ischemic stroke, millions of neurons die by the minute. For those who are eligible for thrombolytic therapy, the duration of diagnostic DSC-scans are therefore reduced to a minimum. This study shows that this practice may lead to severe underestimation of the perfusion abnormality, and therefore the therapeutic target. The degree of underestimation is investigated for three different deconvolution techniques.