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Abstract #0216

Partial Volume Corrected CMRO2 Determination in a Glioblastoma Patient by 17O MRI

Stefan H. Hoffmann1, Alexander Radbruch1, 2, Wolfhard Semmler1, Armin M. Nagel1

1Dpt. of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 2Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany

In tumor cells energy production is shifted from aerobic to anaerobic metabolization of glucose and reduced CMRO2 was found in brain tumors in 15O PET studies. We present an 17O2 inhalation experiment performed in a glioblastoma patient. Direct 17O MRI was carried out to quantify CMRO2 in brain tissue and in the tumor region. Partial volume correction was applied to the dynamic data before CMRO2 determination. The data showed reduced CMRO2 in the tumor center and perifocal edema compared to brain tissue. The CMRO2 values we obtained by 17O MRI agree well with previous PET results.