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Abstract #0219

in vivo Evidence for Abnormal Cerebral Bioenergetics in Schizophrenia Measured by 31P Magnetization Transfer Spectroscopy

Fei Du1, Alissa Cooper2, Thida Thida2, Selma Sehovic2, Scott Lukas1, Bruce Cohen1, Xiaoliang Zhang3, Dost Ongur1

1McLean Hospital, Harvard Medical School, Belmont, MA, United States; 2McLean Hospital, Belmont, MA, United States; 3Department of Radiology, University of California, San Francisco, San Francisco, CA, United States

Schizophrenia (SZ) is a common and severe brain disorder associated with poor functional outcome. Despite suggestions of abnormal mitochondrial and bioenergetic function in SZ, creatine kinase (CK) reaction rate, a direct biomarker of bioenergetics, has not previously been measured in vivo. Here, we report our primary results using a novel 31P MRS approach; the CK reaction rate was found a substantial reduction in SZ. Therefore we provided first direct and compelling in vivo evidence for a specific bioenergetic abnormality in SZ, which would provide crucial information for understanding underlying molecular mechanism, and novel targets for drug development in SZ.