Abstract #0234

Casein Coated Magnetic Iron Oxide Nanoparticles for Targeted Imaging and Drug Delivery

Jing Huang¹, Hyunseok Kang², Liya Wang¹, Run Lin¹, Xianghong Peng², Lily Yang³, Dong Moon Shin², Hui Mao⁴

¹Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States; ²Department of Haematology and Oncology, Emory University, Atlanta, GA, United States; ³Department of Surgery, Emory University, Atlanta, GA, United States; ⁴1. Department of Radiology and Imaging Sciences, 2. Center for Systems Imaging, Emory University, Atlanta, GA, United States

Magnetic iron oxide nanoparticles have shown not only superb MRI contrast enhancement for improving diagnostic sensitivity but also unique capability of imaging guided drug delivery to facilitate the treatment. Here we report the development of a novel theranostic nanoplatform that is composed of milk protein casein coated magnetic iron oxide nanoparticles (CNIOs), near infrared dye Cy5.5, chemotherapy agent cisplatin (cis) and targeting ligand folic acid (FA). We demonstrated that Cy5.5-FAIO-cis are highly efficient in drug delivery and inhibiting tumor growth. Furthermore, the drug delivery process could be monitored by in vivo NIR/MR imaging in cancer animal models.