Jing Huang1,
Hyunseok Kang2, Liya Wang1, Run Lin1,
Xianghong Peng2, Lily Yang3, Dong Moon Shin2,
Hui Mao4
1Department
of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United
States; 2Department of Haematology and Oncology, Emory University,
Atlanta, GA, United States; 3Department of Surgery, Emory
University, Atlanta, GA, United States; 41. Department of
Radiology and Imaging Sciences, 2. Center for Systems Imaging, Emory
University, Atlanta, GA, United States
Magnetic iron oxide nanoparticles have shown not only superb MRI contrast enhancement for improving diagnostic sensitivity but also unique capability of imaging guided drug delivery to facilitate the treatment. Here we report the development of a novel theranostic nanoplatform that is composed of milk protein casein coated magnetic iron oxide nanoparticles (CNIOs), near infrared dye Cy5.5, chemotherapy agent cisplatin (cis) and targeting ligand folic acid (FA). We demonstrated that Cy5.5-FAIO-cis are highly efficient in drug delivery and inhibiting tumor growth. Furthermore, the drug delivery process could be monitored by in vivo NIR/MR imaging in cancer animal models.