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Abstract #0263

Myocardial ATP Turnover Rates in the in vivo Hearts with Post-Infarction Remodeling

Qiang Xiong1, Pengyuan Zhang1, Lei Ye1, Jinfeng Tian1, Cory Swingen1, Albert Jang1, J. Thomas Vanghan1, Jianyi Zhang1

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

A novel indirect magnetization saturation transfer (MST) approach is developed to allow measurement of ATP→Pi reaction rate without quantification of inorganic phosphate (Pi) levels, thus avoided the primary barrier for applications in in vivo heart. With the new approach, myocardial ATP→Pi reaction rate was measured in Normal and post-infarct hearts with or without stem cell therapy. The data suggested that the ATP→Pi rate is a sensitive bioenergetic index that is tightly correlated to cardiac workload as well as the severity of post-infarction left ventricular remodeling based on a swine model of post-infarction LV remodeling.