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Abstract #0270

How Much Resolution Is Needed for in-vivo Analysis of Cortical Myeloarchitecture?

Miriam Waehnert1, Juliane Dinse1, 2, Christine Lucas Tardif1, Andreas Schfer1, Stefan Geyer1, Pierre-Louis Bazin1, Robert Turner1

1Department of Neurophysics, Max-Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 2Faculty of Computer Science, OvGU Magdeburg, Magdeburg, Germany

Intra-cortical T1 contrast reflects myeloarchitecture in the living human brain. Profiles can be constructed on MRI of quantitative T1 maps in 3D and used to detect cortical areal boundaries. Here we explore the effect of spatial resolution on the distinguishability of cortical architecture. We compare cortical profiles from the neighbouring Brodmann areas 1, 3b and 4 from T1 maps with isotropic resolutions of 0.5 mm and 0.7 mm. The standard deviations of the average profiles are mostly smaller at higher resolution. Moreover, the shapes of cortical profiles are similar at 0.7 mm, whereas they are Brodmann-area specific at 0.5 mm.