Abstract #0282

Comprehensive Assessment of Diffuse Liver Disease with Quantitative MRI Biomarkers of Steatosis, Fibrosis and Portal Flow: A Biopsy Correlation Study.

Alejandro Roldn-Alzate¹, Alejandro Muoz del Rio¹, Rashmi Agni², Adnan Said³, Oliver Wieben¹,⁴, Scott B. Reeder¹,⁴

¹Radiology, University of Wisconsin, Madison, WI, United States; ²Pathology, University of Wisconsin, Madison, WI, United States; ³Hepatology, University of Wisconsin, Madison, WI, United States; ⁴Medical Physics, University of Wisconsin, Madison, WI, United States

NAFLD is the most common type of chronic liver disease and a large and increasing number of NAFLD patients develop cirrhosis and liver. In this study we investigated the relationship between liver stiffness, fat content and portal venous flow using MRI compared to biopsy, in patients with diffuse liver disease. Results show positive correlation between normalized portal flow and liver stiffness, and a negative correlation between fat content and stiffness (independent of fibrosis). The combination of quantitative MRI biomarkers for fat content, stiffness and portal blood flow may provide comprehensive assessment for the diagnosis and treatment monitoring of diffuse liver disease.