1Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States; 2Robin Medical, Inc, Baltimore, MD, United States
In this work we propose a novel motion robust high-resolution FLASH acquisition scheme to be used for cortical lesion detection in uncooperative subjects. This scheme is based on acquiring multiple low-resolution images with different orientations and then combining these acquisitions into an isotropic high-resolution image using super-resolution reconstruction. We use a motion sensor to identify the low-resolution images corrupted with motion to reacquire them, as well as to correct for the motion between the low-resolution acquisitions. With this method whole brain images with isotropic resolution of 0.6 mm were reconstructed with a total scan time of 20 minutes.