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Abstract #0335

A Modified Photothrombotic Stroke Model Using Implantable Optic Fiber: In-Bore Stroke Induction for Probing Peri-Infarct Spreading Depolarization

Yu-Chieh Jill Kao1, Hsin-Yi Lai1, Chris Kao1, Yen-Yu Ian Shih1

1Experimental Neuroimaging Laboraory, Department of Neurology and Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States, Chapel Hill, NC, United States

A photothrombotic stroke model using implantable optic fiber (IOF photothrombosis) was proposed in rats to visualize ADC and CBF changes before, during and after stroke onset. Peri-infarct spreading depolarization (PID) and post-PID oligemia were demonstrated for the first time by high resolution diffusion/perfusion MRI. IOF photothrombosis is highly feasible to create ischemic lesion in predetermined brain area with well-controlled infarct size, which opens up new avenues for preclinical stroke research.