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Abstract #0343

Microtubule Stabilizer Ameliorates Functional Connectivity in a MAP6 Deficient Mouse: A Manganese Enhanced Magnetic Resonance Imaging Study

Alexia Daoust1, 2, Emmanuel Luc Barbier1, 2, Annie Andrieux1, 2, Sylvain Bohic1, 3, Jean-Chritophe Deloulme1, 2

1INSERM U836, grenoble, France; 2Universit Joseph Fourier, Grenoble institut des neurosciences, grenoble, France; 3European Synchrotron Radiation Facility, grenoble, France

The STOP/MAP6 null mouse is a microtubule-deficient model of schizophrenia. Using MEMRI, we traced the cortico-thalamic tract after MnCl2 injection in the primary somatosensory cortex. Twenty-four hours after injection, the MRI relative signal intensity revealed that polysynaptic thalamo-cortical and cortico-pontic tracts were affected but not the monosynaptic tracts. These alterations were reversed after administration of a microtubule stabilizer to the animals.