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Abstract #0361

Assessing Lower-Extremity Hemodynamics in Individuals with Diabetes

Jie Zheng1, Mary K. Hasting1, iaodong Zhang2, Andrew Coggan1, Hongyu An3, David Muccigrosso1, Darrah Snozek1, Adil Bashir1, Robert J. Gropler1, Michael Mueller4

1Washington University in St. Louis, Saint Louis, MO, United States; 2Peking University First Hospital, Beijing, China; 3University of North Carolina, Chapel Hill, NC, United States; 4Physical Therapy, Washington University in St. Louis, Saint Louis, MO, United States

A newly developed non-contrast MRI oximetry method was applied to evaluate skeletal muscle perfusion and oxygenation in individuals with diabetes mellitus. The study was performed in 4 healthy volunteers and 4 age-matched diabetic patients, at rest and during sustained isometric exercise. Significant attenuations in muscle perfusion and oxygenation were clearly observed in diabetic patients.