Abstract #0361

Assessing Lower-Extremity Hemodynamics in Individuals with Diabetes

Jie Zheng¹, Mary K. Hasting¹, iaodong Zhang², Andrew Coggan¹, Hongyu An³, David Muccigrosso¹, Darrah Snozek¹, Adil Bashir¹, Robert J. Gropler¹, Michael Mueller⁴

¹Washington University in St. Louis, Saint Louis, MO, United States; ²Peking University First Hospital, Beijing, China; ³University of North Carolina, Chapel Hill, NC, United States; ⁴Physical Therapy, Washington University in St. Louis, Saint Louis, MO, United States

A newly developed non-contrast MRI oximetry method was applied to evaluate skeletal muscle perfusion and oxygenation in individuals with diabetes mellitus. The study was performed in 4 healthy volunteers and 4 age-matched diabetic patients, at rest and during sustained isometric exercise. Significant attenuations in muscle perfusion and oxygenation were clearly observed in diabetic patients.