Jun Hua1, 2, Paul G. Unschuld3, 4, Russell L. Margolis3, 5, Peter C.M. van Zijl1, 2, Christopher A. Ross3, 6
Neurovascular alterations have been implicated in the pathophysiology of Huntingtons Disease (HD). As arterioles are most responsive to metabolic alterations, arteriolar cerebral blood volume (CBVa) is an important indicator of cerebrovascular regulation. We show that cortical CBVa, measured with the inflow-based vascular-space-occupancy (iVASO) MRI technique, is significantly elevated in prodromal HD patients, and this effect correlates with genetic measures. By contrast, no significant brain atrophy was detected in these prodromal HD patients. Our results suggest CBVa as a potential biomarker prior to prominent brain atrophy in prodromal HD.