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Abstract #0383

CEST MR Imaging Investigation of Parkinson Disease at 3 T

Chunmei Li1, Xuna Zhao2, Rui Wang1, Shuai Peng1, Cheng Zhou1, Jinyuan Zhou3, Min Chen1

1Department of Radiology, Beijing Hospital of the Ministry of Health, Beijing, China; 2Peking University, Beijing, China; 3Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

Chemical exchange saturation transfer (CEST) imaging is a novel molecular MRI technique that can generate image contrast based on the endogenous or exogenous, low-concentration chemicals. We performed CEST imaging experiments on patients with PD. The CEST signals at the offset of 3.5ppm of caudate, putamen and globus pallidus in PD patients was significantly higher than normal controls, while the CEST signal at the offset of 1.5ppm of substantia nigra was significantly lower in PD patients than normal controls.