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Abstract #0415

Simultaneous Spin Echo and Gradient Echo for fMRI Using the USPIO Agent Ferumoxytol in Humans: Enhanced Sensitivity and Potentials for High Resolution Mapping

Deqiang Qiu1, Thomas Christen1, Wendy W. Ni1, Heiko Schmiedeskamp1, Greg Zaharchuk1, Michael E. Moseley1

1Radiology, Stanford University, Stanford, CA, United States

In this paper, we present the study of the use of ultrasmall superparamagnetic iron particle (USPIO) for fMRI (termed ICE-BVI) using both gradient and spin echo methods. The contrast to noise ratio (CNR) of ICE-BVI was found to be of up to a factor of 3.8 higher than BOLD for gradient echo based method, and the gain is about a factor of 2 for spin echo based method. ICE-BVI has the potential of increasing robustness and accuracy for presurgical mapping and enhanced sensitivity in studying cognitive neuroscience.