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Abstract #0436

CubeQuant T1rho, QDESS T2, and Cones Sodium Measurements Are Sufficiently Reproducible for In Vivo Cartilage Studies

Caroline D. Jordan1, 2, Uche D. Monu1, 3, Emily J. McWalter1, Ronald D. Watkins1, Weitian Chen4, Neal K. Bangerter5, Brian Andrew Hargreaves1, Garry E. Gold1, 6

1Radiology, Stanford University, Stanford, CA, United States; 2Bioengineering, Stanford University, Stanford, CA, United States; 3Electrical Engineering, Stanford University, Stanford, CA, United States; 4Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 5Electrical & Computer Engineering, Brigham Young University, Provo, UT, United States; 6Orthopaedic Surgery, Stanford University, Stanford, CA , United States

Quantitative MRI parameters such as T1&[rho], T2 and sodium have been shown to vary in osteoarthritis patients. We measured the reproducibility of the 3D quantitative MRI techniques of CubeQuant T1&[rho], qDESS T2 and cones sodium measurements in knee cartilage. Intra-observer, inter-observer, adjacent slice, and short-term/long-term intra-subject variability were measured by computing the coefficient of variation (CV). The short-term and long-term intra-subject reproducibility amongst different regions of cartilage, expressed by the root-mean-square CV, ranged between 2.7-8.6% and 4.6-9.0% for CubeQuant T1&[rho], between 2.4-9.8% and 4.4-13.8% for qDESS T2, and between 5.2-13.8% and 4.6-16.0% for 3D cones sodium MRI, respectively.