Abstract #0457

7T MRSI in Temporal Lobe Epilepsy

David Bonekamp¹, He Zhu¹, Gregory Bergey², Peter B. Barker¹

¹The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; ²Department of Neurology, Johns Hopkins University, Baltimore, MD, United States

In this study, control subjects and a cohort of epilepsy patients with a clinical diagnosis of unilateral epilepsy underwent MRSI at 7T. Similar to prior studies at lower fields, 7T MRSI of the hippocampi showed bilateral mid-hippocampal tNAA decreases, accentuated at the side of clinical and MRI abnormality. Lateralization of the clinical focus was not possible, due to significant contralateral tNAA decrease. Future comparative studies are needed to compare the relative value of 7T vs. 3T MRSI, as well as the relative value of 7T MRSI to other MRI sequences, in patients with temporal lobe epilepsy.