Abstract #0473

Accelerated, Motion-Corrected High-Resolution Intravascular MRI at 3T

Shashank Sathyanarayana Hegde¹, Yi Zhang², Paul A. Bottomley¹

¹Radiology, Johns Hopkins University, Baltimore, MD, United States; ²Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United States

High-resolution intravascular (IV) MRI is susceptible to degradation from physiological motion, and requires high frame-rates for true endoscopy. Fortunately, IV MRI detectors have intrinsically radial and sparsely-localized sensitivity profiles, and high local signal-to-noise ratios. Here, compressed sensing with sparse reconstruction is combined with motion correction using frame-by-frame projection shifting based on a singularity at the probes location, to provide up to four-fold effective speed-up in image acquisition and a significant reduction in motion sensitivity. We present data acquired in phantoms, and human vessel specimens. These strategies can greatly facilitate high-resolution (~100 micron) real-time MRI endoscopy.