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Abstract #0496

dPFG MRI Assessment of Axonal Beading in an Injury Model

Michal E. Komlosh1, 2, Dan Benjamini1, 3, Matthew D. Budde4, Lynne A. Holtzclaw5, Martin J. Lizak6, Ferenc Horkay1, Uri Nevo3, Peter J. Basser1

1NICHD/PPITS/STBB, NIH, Bethesda, MD, United States; 2CNRM, USUHS, Bethesda, MD, United States; 3Department of Biomedical Engineering, The Iby and Aladar Fleischman Faculty of Engineering, Tel-Aviv University, Tel Aviv, Israel; 4Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States; 5NICHD/SCBS, NIH, Bethesda, MD, United States; 6NINDS/MIF, NIH, Bethesda, MD, United States

dPFG MRI was used to characterize the microstructure of an injury model using rat sciatic nerve. Three samples were used in this study, one injured nerve and two controls. A theoretical model was used to fit the resulting dPFG MRI data in order to detect alterations in tissue microstructure.