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Abstract #0499

Investigating Quantitative Imaging Biomarkers of Response to Cabozantinib in a VCaP Model of Prostate Bone Metastasis

Timothy James Graham1, Gary Box2, Ruth Riisnaes2, Susana Miranda2, Gerhardt Attard2, Johann S. de Bono2, Suzanne A. Eccles2, Faith E. Davies2, Simon P. Robinson1

1Division of Radiotherapy and Imaging, The Institute of Cancer Research, Sutton, Surrey, United Kingdom; 2Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, Surrey, United Kingdom

With the development of more targeted therapeutics to treat malignant bone disease has come the associated challenge of developing more clinically relevant pre-clinical models, and identifying new non-invasive techniques capable of assessing the tumour phenotype and treatment response. To this end, a mouse model of castrate-resistant, prostate bone metastasis, propagated by direct intraosseous injection of cells, and its response to cabozantinib, has been investigated by quantitative imaging methods.