Abstract #0506

Comparison of Arterial Spin Labelling and R2* as Predictive Response Biomarkers for Vascular Targeting Agents in Liver Metastases

Sean Peter Johnson¹, Rajiv Ramasawmy², Adrienne E. Campbell-Washburn², Mathew Robson¹, Jack Wells², Vineeth Rajkumar¹, Simon Walker-Samuel², Mark F. Lythgoe², Rosamund Barbara Pedley¹

¹Cancer Institute, University College London, London, Greater London, United Kingdom; ²Centre for Advanced Biomedical Imaging, University College London, London, Greater London, United Kingdom

We present data comparing the ability of arterial spin labelling (ASL) perfusion measurements and R2* to assess response to vascular disrupting agent therapy in a mouse liver metastasis model. A significant increase in R2* (p<0.01, n=12) and a significant decrease in perfusion (p<0.01, n=18) were measured. Baseline perfusion was significantly correlated with the subsequent change in perfusion at 90 minutes following therapy, whilst baseline R2* values did not show a relationship with response. No significant correlation was found between perfusion and R2* post-therapy changes.