Sofie Van Cauter1, Diana M. Sima2, Anca R. Croitor Sava2, Jelle Veraart3, Stefan Sunaert1, 4, Sabine Van Huffel2, Uwe Himmelreich5
1Radiology, University Hospitals of Leuven, Leuven, Vlaams-Brabant, Belgium; 2ESAT-PSI, Department of Electrical Engineering, Catholic University of Leuven, Heverlee, Vlaams-Brabant, Belgium; 3Vision Lab, Department of Physics, University of Antwerp, Antwerp, Belgium; 4Translational MRI, University Hospitals of Leuven, Leuven, Vlaams-Brabant, Belgium; 5Biomedical NMR Unit/Molecular Small Animal Imaging Center, Department of Medical Diagnostic Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium
Current routinely used MR techniques are often insufficient in accurate grading of glioma. Hence, in most cases a biopsy is warranted in order to obtain a definitive diagnosis. In this study, we assessed the diagnostic accuracy of diffusion kurtosis imaging, dynamic susceptibility-weighted magnetic resonance imaging and short echo time chemical shift imaging for grading gliomas. The most accurate parameters for determination of glioma grade were mean kurtosis and mean relative regional cerebral blood flow. However, a combination between calculated parameters could still provide a better differentiation between high- and low-grade glioma in this data set.