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Abstract #0559

New Approaches in B1-Mapping Compensation for in Vivo Quantitative 19F MR Molecular Imaging Using UTE BSSFP

Matthew J. Goette1, Todd A. Williams1, John S. Allen1, Jochen Keupp2, Gregory M. Lanza1, Samuel A. Wickline1, Shelton D. Caruthers1

1C-TRAIN, Washington University in St. Louis, St. Louis, MO, United States; 2Philips Research Europe, Hamburg, Germany

This study presents a strategy to more accurately quantify the sparse 19F signal from alpha-v-beta-3-integrin targeted perfluorocarbon nanoparticle emulsions with a 1H image-based Actual Flip Angle B1-mapping correction to the 19F and 1H images, acquired with a simultaneous dual-frequency ultra-short echo time balanced steady state free precession sequence, in an in vivo setting using a VX2 tumor model implanted into rabbits.