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Abstract #0578

Human Cardiac 31P Magnetic Resonance Spectroscopy at 7 Tesla

Christopher T. Rodgers1, William T. Clarke2, Carl Snyder3, University of Minnesota University of Minnesota Vaughan3, Stefan Neubauer1, Matthew D. Robson1

1Univ Oxford, Oxford, United Kingdom; 2University of Oxford, Oxford, United Kingdom; 3CMRR, Univ Minnesota, Minneapolis, MN, United States

Cardiac 31P spectroscopy (31P-MRS) provides unique insights into the supply of energy in the heart. However, clinical applications of cardiac 31P-MRS have suffered from a low intrinsic signal-to-noise ratio (SNR). We demonstrate 31P-MRS for the first time in the human heart at 7T. We compare quantitatively the performance at 7T against that at 3T in a study on 9 normal volunteers. The measured SNR for PCr increases by 2.8x, the Cramer-Ro lower bounds on PCr concentration decrease 4.3x and the PCr/ATP ratio SD decreases by 2x. Clearly, cardiac 31P-MRS at 7T shows great promise.