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Abstract #0582

A Radial 3D GRE-EPI Pulse Sequence with kz Blip Encoding for Whole-Brain Isotropic 3D Perfusion Using DSC-MRI Bolus Tracking with Sliding Window Reconstruction (3D RAZIR)

Sumeeth Vijay Jonathan1, Parmede Vakil1, Yong Jeong1, Sameer A. Ansari2, Michael Hurley2, Bernard R. Bendok3, Timothy J. Carroll1, 2

1Biomedical Engineering, Northwestern University, Chicago, IL, United States; 2Radiology, Northwestern University, Chicago, IL, United States; 3Neurological Surgery, Northwestern University, Chicago, IL, United States

3D RAZIR obtains 76-slice whole-brain relative perfusion measurements with DSC-MRI bolus tracking at 1.7 mm3 isotropic voxel resolution. Consecutive 3D volumes are acquired in 10.3 s, but we recover dynamic bolus information at 160 ms per frame using sliding window reconstruction. 3D RAZIR uses in-plane radial sampling and through-plane Cartesian sampling with 3D GRE-EPI readouts to allow sliding window reconstruction, which permits increased volume coverage without sacrificing SNR for bolus tracking. Radial view-dependent N/2 ghosting artifacts are corrected using inline phase correction scans. 3D RAZIR obtains whole-brain perfusion maps of rCBF, rCBV, and MTT with good reference standard agreement.