Dingxin Wang1, 2, Charles G. Cantrell3, Bruce S. Spottiswoode4, Vibhas Deshpande5, Timothy J. Carroll3, Keith A. Heberlein6
1Siemens Medical Solution USA, Inc., Minneapolis, MN, United States; 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 3Department of Radiology, Northwestern University, Chicago, IL, United States; 4Siemens Medical Solutions USA, Inc., Chicago, IL, United States; 5Siemens Medical Solutions USA, Inc., Austin, TX, United States; 6Siemens Healthcare USA, Charlestown, MA, United States
Our study demonstrates the feasibility of using slice accelerated EPI for DSC-MRI measurement and shows the evidence of association between sampling TR and perfusion parameters. The MTT and Tmax maps with faster TR sampling (509 ms) of perfusion data provide more image contrast than slower sampling rate (1527 ms). The difference in MTT also contributes to the variation of CBF spatial pattern. Faster data acquisition should reduce discretization errors in the perfusion measurement, especially for Tmax, as the measured Tmax is rounded-off to a value multiple of TR.