University of Wisconsin, Madison, WI, United States; 2Radiology,
University of Wisconsin-Madison, Madison, WI, United States; 3Medical
Physics, University of Wisconsin, Madison, WI, United States
Apparent diffusion coefficient (ADC) measurements are confounded by the presence of fat. This has important clinical implications as many organs such as the breast, liver and bone marrow contain fat. We developed a single-voxel diffusion-weighted (DW) spectroscopic sequence that allows ADC measurements corrected for the confounding effect of fat. Phantom experiments and in vivo measurements in the spinal bone marrow, breast and liver were performed. ADCs were compared to corresponding values obtained from conventional DW echo-planar imaging (DW-EPI). The two techniques were in agreement when the fat content was low but DW-EPI substantially underestimated ADC for higher fat fractions.