Meeting Banner
Abstract #0612

Cognitive Reserve Modulates the Defaul Mode Network in Patients with MCI and AD

Marco Bozzali1, Claire Dowling2, Laura Serra3, Barbara Spano'3, Carlo Caltagirone4, 5, Mara Cercignani6

1Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; 2School of Life Sciences, University of Sussex, Brighton, United Kingdom; 3Neuroimaging Laboratory, IRCSS Santa Lucia, Rome, Italy; 4Dept of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy; 5Dept. of NeuroScience, University of Rome "Tor Vergata", Rome, Italy; 6CISC, Brighton & Sussex Medical School, Brighton, United Kingdom

This paper investigates the relationship between functional connectivity of the default mode network (DMN) and "cognitive reserve", measured by education and occupation, in patients with MCI and AD. Results support the hypothesis that modulation of connectivity occurs in the posterior cingulate, one of the key nodes of the DMN.