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Abstract #0615

ROI-Based Analysis of Diffusional Kurtosis Estimates for Identification of MCI-Patients at High Risk for Conversion to Alzheimers Disease in a Heterogeneous MCI Cohort

Daniel Svrd1, 2, Filip Szczepankiewicz3, Jimmy Ltt2, Markus Nilsson4, Sebastian Palmqvist5, 6, Katarina Ngga5, Oskar Hansson5, 6, Danielle van Westen1, 2

1Diagnostic Radiology, Clinical Sciences Lund, Lund University, Lund, -, Sweden; 2Center for Medical Imaging and Physiology, Skane University Hospital, Lund, Lund, -, Sweden; 3Medical Radiation Physics, Lund University, Lund, -, Sweden; 4Lund BioImaging Center, Lund University, Lund, -, Sweden; 5Clinical Memory Research Unit, Department of Clinical Sciences Malm, Malm, -, Sweden; 6Department of Neurology, Skane University Hospital Lund, Lund, -, Sweden

The potential of Diffusional Kurtosis Imaging (DKI) for differentiation of patients with pathological CSF (MCIp-CSF) from MCI-patients without pathological CSF (MCInp-CSF) and from controls was probed for using ROI-based analysis. Diffusivity changes were present in some areas. Kurtosis parameters MK and RK did not outperform diffusion parameters MD and FA.