Abstract #0620

Hippocampal Volumes in Subjects at Risk of Alzheimer's Disease with a New Registration Template

Bernd Merkel¹,², Nicola T. Lautenschlager³, Christopher Steward,²⁴, Lucy Vivash⁵, Bob Tran⁴, David Ames⁶, Kay Cox⁷, Elizabeth Cyarto⁶, Kathryn Ellis³, Pramit Phal⁴, Matthew Sharman⁸, Cassandra Szoeke⁹, Patricia M. Desmond,²⁴

¹University of Melbourne , Parkville, Victoria, Australia; ²Radiology, Royal Melbourne Hospital, Parkville, Victoria, Australia; ³University of Melbourne, Kew, Victoria, Australia; ⁴University of Melbourne, Parkville, Victoria, Australia; ⁵Medicine, University of Melbourne, Parkville, Victoria, Australia; ⁶National Ageing Research Institute, Parkville, Victoria, Australia; ⁷University of Western Australia, Perth, Western Australia, Australia; ⁸Edith Cowan University, Joondalup, Western Australia, Australia; ⁹CSIRO, Parkville, Victoria, Australia

In Alzheimers Disease (AD), the hippocampus is one of the first regions in the brain being affected. The loss of hippocampal volume over time and its measurement with MRI has been proven a potential valuable biomarker for early diagnosis. However, accurate determination is still challenging. We created a new registration template based on healthy elderly people and calculated hippocampal volumes of patients with subjective memory complaints (SMC) and mild cognitive impairments (MCI), which are under higher risk of developing AD. These results were compared with manual segmentation as well as widely accepted software packages volumes.