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Abstract #0620

Hippocampal Volumes in Subjects at Risk of Alzheimer's Disease with a New Registration Template

Bernd Merkel1, 2, Nicola T. Lautenschlager3, Christopher Steward, 24, Lucy Vivash5, Bob Tran4, David Ames6, Kay Cox7, Elizabeth Cyarto6, Kathryn Ellis3, Pramit Phal4, Matthew Sharman8, Cassandra Szoeke9, Patricia M. Desmond, 24

1University of Melbourne , Parkville, Victoria, Australia; 2Radiology, Royal Melbourne Hospital, Parkville, Victoria, Australia; 3University of Melbourne, Kew, Victoria, Australia; 4University of Melbourne, Parkville, Victoria, Australia; 5Medicine, University of Melbourne, Parkville, Victoria, Australia; 6National Ageing Research Institute, Parkville, Victoria, Australia; 7University of Western Australia, Perth, Western Australia, Australia; 8Edith Cowan University, Joondalup, Western Australia, Australia; 9CSIRO, Parkville, Victoria, Australia

In Alzheimers Disease (AD), the hippocampus is one of the first regions in the brain being affected. The loss of hippocampal volume over time and its measurement with MRI has been proven a potential valuable biomarker for early diagnosis. However, accurate determination is still challenging. We created a new registration template based on healthy elderly people and calculated hippocampal volumes of patients with subjective memory complaints (SMC) and mild cognitive impairments (MCI), which are under higher risk of developing AD. These results were compared with manual segmentation as well as widely accepted software packages volumes.