Yijing Wu1, Jane Maksimovic2, Patrick Turski2, Charles A. Mistretta3
1Medical Physics, University of Wisconsin, Madison, WI, United States; 2Radiology, University of Wisconsin, Madison, WI, United States; 3Medical Physics and Radiology, University of Wisconsin, Madison, WI, United States
High resolution time-resolved contrast-enhanced MRA using hybrid HYPR reconstruction (4D Hybrid HYPR MRA) is able to provide sub-second temporal resolution and sub-millimeter isotropic spatial resolution with whole brain coverage. However, due to the significant dispersion of the contrast bolus resulting from the circulation through the heart and lungs after the venous injection contrast, it is very challenge to achieve similar temporal effects as using the x-ray DSA. Time-of-arrival (TOA) map can be estimated from the 4D MRA dataset and provide quantitative description of contrast material arrival time in each voxel. In this project, we propose to combine the TOA map with the Hybrid HYPR MRA to further enhance the visualization of contrast kinetics and display DSA like bolus tracing with intravenous injection.