Fang Liu1, Samuel A. Hurley1, Alexey Samosonov1, Andrew L. Alexander1, Sean C. L. Deoni2, Walter F. Block1, 3, Richard Kijowski4
1Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2Division of Engineering, Brown University, Providence, RI, United States; 3Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States; 4Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States
Multi-component T2 mapping using mcDESPOT three pool model was performed for correcting synovial fluid partial volume contamination in human knee cartilage in-vivo scan at 3.0T. T2 relaxation time for the bulk water loosely bound to the proteoglycan matrix (Wb) were shown to be mostly affected at the superficial layer of the cartilage with increasing T2 values more than 100% compared to the deep layer. mcDESPOT three pool model shows significant advantage of correcting the T2 relaxation time estimation bias while has no influence on measurements within the remaining portions of the cartilage.