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Abstract #0674

in vivo Assessment of Fatty Diabetic Kidney by Diffusion Weighted and BOLD MRI in Rats

Koji Sagiyama1, Orson W. Moe2, Masaya Takahashi1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Mineral Metabolism/Internal Medicine, University of Texas Southwestern Medical Center, Dalla, TX, United States

Our previous studies in murine models of unilateral ureteral obstruction and dietary phosphate overload have shown excellent correlation between MRI and kidney histopathology, where the apparent diffusion constant (ADC) determined by DW-MRI inversely correlates with the severity of fibrosis. It has also been shown that blood oxygen level dependent (BOLD) MRI measures renal hypoxia where hypoxic tissue shows lower T2*. The purpose of this study was to test our hypothesis that a combination of DW- and BOLD-MRI would reflect histopathological and functional changes in vivo in the kidney with type II diabetes.