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Abstract #0677

A Novel Technique for Global Small Bowel Motility Assessment Using Dynamic MRI

Alex Menys1, Stuart A. Taylor1, Anton Emmanuel2, Asia Ahmed1, Andrew Plumb1, Freddy Odille3, 4, Ahsan Alam2, Steve Halligan1, David Atkinson1

1Centre for Medical Imaging, UCL, London, UK, United Kingdom; 2GI Physiology UCLH, London, UK, United Kingdom; 3INSERM U947, Nancy, France; 4IADI, Universit de Lorraine, Nancy, France

Aberrant small bowel motility is described in a range of diseases including chronic intestinal pseudo-obstruction, Crohns disease and irritable bowel syndrome. Few tools exist to investigate abnormal motility and those that do are often invasive and fail to assess the whole of the small bowel. This article describes the validation of a novel MRI technique which safely and non-invasively quantifies global small bowel motility, reporting within-subject repeatability in healthy human subjects and sensitivity to the motility altering drugs butylscopolamine and neostigmine.