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Abstract #0692

Dynamic Magnetic Property of Multiple Sclerosis Lesions at Various Ages Measured by Quantitative Susceptibility Mapping

Weiwei Chen1, Susan A. Gauthier2, Ajay Gupta2, Joseph Comunale2, Tian Liu2, Shuai Wang3, Mengchao Pei2, David Pitt4, Yi Wang2

1Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; 2Weill Cornell Medical College, New York, NY, United States; 3School of Electronic Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China; 4The Ohio State University, Columbus, OH, United States

A total of 293 MS lesions were detected in 12 clinically definite MS patients who underwent twice quantitative susceptibility mapping (QSM) from 8/2011 to 5/2012. This longitudinal study of susceptibilities of MS lesions of different ages using QSM suggests the following findings. 1) There are 6 patterns of lesions manifested in MRI, with various patterns in individual patients. 2) QSM can detect lesions that are not detectable on conventional MRI (pattern Q). 3) Susceptibilities of MS lesions increase at early stage, peak in 1-3 yrs, subsequently decrease in 3-7 yrs, and return to normal after 7 yrs.