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Abstract #0698

Model-Based Super-Resolution of Diffusion MRI for Microstructure Imaging

Alexandra Tobisch1, Hui Zhang2

1Department of Medical Physics and Bioengineering, University College London, London, United Kingdom; 2Department of Computer Science and Centre for Medical Image Computing, University College London, London, United Kingdom

This work develops a super-resolution reconstruction (SRR) technique that constructs isotropic high-resolution diffusion-weighted images (DWI) from multiple anisotropic low-resolution acquisitions. The technique will enable the mapping of tissue microstructure for fine brain structures without the need for prohibitively long imaging time. It advances the state-of-the-art by adopting a model-based approach to directly super-resolve the parameter maps of the underlying tissue microstructure.