Chunlei Liu1, 2, Wei Li1
1Brain Imaging and Analysis Center, Duke University, Durham, NC, United States; 2Radiology, Duke University, Durham, NC, United States
Using a multipole analysis in the Fourier spectral space, we developed a high-resolution method that enables the quantification of tissues magnetic response with a set of multipole susceptibility tensors of various ranks. The Fourier spectral space, termed p-space, can be generated by applying field gradients or equivalently by shifting the k-space data in various directions. We performed p-space susceptibility tensor imaging in simulation and on mouse brains ex vivo, illustrating capabilities of mapping white matter fiber orientations. These experiments demonstrate that multipole tensors may enable practical mapping of tissue microstructure in vivo without rotating subject or magnetic field.