1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Philips Medical Systems, Cleveland, OH, United States; 3University of Vermont College of Medicine, Burlington, VT, United States; 4Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Research Institute, Toronto, Ontario, Canada; 5Department of Population, Family, and Reproductive Health, Johns Hopkins University, Baltimore, MD, United States; 6Department of Neurology, Johns Hopkins University, Baltimore, MD, United States; 7Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States; 8Department of Radiology, Hospital of the University of Montreal, Montreal, Quebec, Canada; 9Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 10Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States
Venous blood oxygenation (Yv) is critical for the quantification of CMRO2, a key biomarker for brain tissue viability and functionality. However, non-invasive quantification of Yv has proved to be challenging. Recently, a T2-Relaxation-Under-Spin-Tagging (TRUST) MRI technique was developed to measure global Yv in the superior sagittal sinus. In this work, we evaluated the applicability and reliability of TRUST in a multi-site setting. We compared Yv values (i.e. accuracy) and standard errors of Yv estimation (i.e. precision) across six imaging centers, and showed that the TRUST sequence can be effectively transferred and performed on a standard 3T scanner at remote sites.