David Shin1, Jerod Rasmussen2, Burak Ozyurt1, Juan Bustillo3, Theodorus GM Van Erp2, Jatin Vaidya4, Daniel Mathalon5, Bryon Mueller6, James Voyvodic7, Douglas Greve8, Judith Ford5, Gary H. Glover9, Gregory Brown1, Steven Potkin2, Thomas Liu1
1University of California, San Diego, La Jolla, CA, United States; 2University of California, Irvine, Irvine, CA, United States; 3University of New Mexico, Albuquerque, NM, United States; 4University of Iowa, Iowa City, IA, United States; 5University of California, San Francisco, San Francisco, CA, United States; 6University of Minnesota, Twin Cities, Minneapolis, MN, United States; 7Duke University, Durham, NC, United States; 8Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States; 9Stanford University, Stanford, CA, United States
In this multisite ASL study, we used a standardized FAIR protocol to measure baseline CBF in 112 healthy controls and gender/age matched 122 schizophrenic patients across 6 sites. CBF processing and group analysis were performed by the CBFBIRN Data Analysis and Processing Pipeline (https://cbfbirn.ucsd.edu). Whole-brain gray matter CBF was significantly lower in patients (52.031.36 ml/100g-min) compared to healthy controls (55.121.36 ml/100g-min). In standard space, voxel-level analysis, schizophrenia was associated with 12 brain regions characterized by hypoperfusion (p<0.01, corrected) including right insula. In contrast, CBF in right putamen was found to be higher with schizophrenia (41.271.72 vs. 34.271.62 ml/100g-min).